Social networking has become one of the most popular and acceptable ways of keeping in touch with friends, family and classmates. The creation of sites like MySpace and Facebook has allowed people to catch up and converse with each other with the click of a mouse. But could this form of communicating be detrimental in more ways than just cheating yourself of spending quality time in person with a friend? Recent studies have shown that health problems can be caused by the lack of face-to-face contact. Psychologist Dr. Aric Sigman claims that "e-mailing someone instead of actually seeing them may have wide ranging biological effects." The increased isolation could alter the way certain genes work and upset immune responses, hormone levels and the function of arteries. There are certain hormones that are activated when interacting with someone in person that you don't get when e-mailing someone. One particular hormone known as the "cuddle chemical," oxytocin, which promotes bonding, is activated when with someone but not when using technological communication. Some genes, including ones that deal with the immune system and responses to stress, also act differently. There is also the risk that constant use of these sites instead of actual in person socialization can impair mental performance.